In the pharmaceutical industry, sterile raw materials undergo refining or synthesis processes to crystallize and obtain drug crystals. The crystalline suspension containing drug crystals is first filtered to separate the crystals from the mother liquor, resulting in a filter cake layer. Then, the filter cake is soaked or rinsed a certain number of times by spraying the washing solution with a washing device. The washing time required for the process. Then, separate the mother liquor again and dry the crystals. After drying for a certain period of time, samples are taken for inspection, and after passing the inspection, they become finished drugs.
Generally speaking, the production of sterile raw materials is usually combined with the refining and sterilization processes of post-treatment products during the production process, and is completed as a step operation unit in the production process. The contamination of sterile and insoluble particles are the two main characteristics that distinguish sterile APIs from non sterile APIs. Therefore, the integration of filtration, washing, and drying is directly related to the production process and quality of the product, and is a method used in the production of sterile raw materials. Major equipment support.
The equipment is equipped with top and bottom adjustment wheels, which can smoothly carry the filter belt during transfer, effectively preventing it from falling off the track. It is also equipped with a low-level cleaning device and a bottom installation cleaning device, which can adjust the filtration of the filter belt twice. This can improve the purity of the filter, including the filter frame and shaping box. The filter cloth forms a closed loop through each filter cloth guide roller. Currently, an annular friction belt is designed between the vacuum box and the tape, forming a motion sealing structure between the vacuum box and the tape, while meeting very effective vacuum sealing requirements.
Due to the use of this device, multiple upper trays are arranged side by side on the upper conveyor belt, and wear-resistant plates are fixed at the top of the upper trays. At present, the use of upper pallets instead of upper rollers significantly reduces the number of parts and the coordination between the belt and the conveyor belt during operation, avoiding the possibility of malfunctions. It always comes with a bracket to lubricate and cool the water being transported, resulting in excellent conveying effect and low failure rate.
This equipment enables materials to complete the three processes of filtration, washing, and monotonicity in a closed container, improving equipment utilization, avoiding environmental pollution, minimizing material transfer losses, saving solvent usage, and suitable for mass production.
The design principle of the three in one filtration, washing, and drying is that the entire cylinder is designed and manufactured according to the pressure vessel, and the entire working process can work in a closed environment. In the filtration stage, the main task is to evacuate the bottom of the tank. To improve filtration efficiency, positive pressure can be used inside the tank, generally not exceeding 0.1MPa. After the filter cake is dried, due to its high density, it can be loosened by reverse cutting and lifting with an S-shaped blade. During the washing process, the forward rotation and lifting of the S-shaped blades will play a stirring role, allowing the washing solution and materials to be thoroughly washed.
